If the purchase goes through it would give the iconic centre a second life after it was closed to streamline operations at Chrysler earlier this year.
The region is synonymous with car design and Mercedes-Benz has its own studio about 51 miles to the north.
According to reports from auto-motor-und-sport, the move would mean that Mercedes-Benz designers would relocate from their current base into the Chrysler centre which is more than double the size.
If Mercedes-Benz moves into the building it will work alongside the Advanced Design Studio in Como in Italy ten years ago.
Another iconic location, the studio is another important link in the designing of the cars of the future.
The latest invention to be born out of the design studios is the F700 Research vehicle which was announced last year.